It was a Suzuki 1-2 after starting with Alex Rins leads his rookie teammate Joan Mir, but the team’s hopes suffered a quick blow when Rins crashed at Turn 9 on lap three.
Soon after, Mir made a mistake and Quartararo taken the lead with Vinales and Marquez among the top three.
With Vinales running wide, Marquez was in second place, putting constant pressure on Quartararo.
The Frenchman was visibly struggling with his Yamaha, his bike shaking several times on the straights and Marquez was finally able to maneuver around him at Turn 6.
But Marquez made a mistake at Turn 1 the next time, allowing Quartararo to retake the lead.
Up to this point, Vinales was all over Marquez but couldn’t move, however the Spaniard finally found a way through shortly after the Honda rider’s error before the Timmer chicane.
Vinales then used another Quartararo bike shake to effortlessly take the lead, with the Frenchman soon falling behind Marquez as well and beginning to struggle to keep up with the duo.
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A second error from Vinales gave Marquez first place, but his lead was again short-lived as his rival pulled off an impressive move on the fast T13 right-hander.
Vinales then extended his lead to half a second, which remained the gap between him and Marquez for several laps.
But with three minutes left, Vinales finally extended the lead to over a second and Marquez was unable to fight back.
Vinales eventually crossed the finish line by 4.8 seconds to take his and Yamaha’s first win since last year’s Phillip Island race.
Marquez finished second and claimed his seventh podium in eight races this year as he extended his championship lead to 44 points Andrea Dovizioso.
Quartararo ended up 9.7 seconds down but still secured the final podium finish, his second consecutive top three finish.
Fourth place was hotly contested between the Ducati duo Andrea Dovizioso and Danilo Petrucci and Mir, with the former taking the position at the end.
SIC Yamaha’s Franco Morbidelli completed the top five as he passed Petrucci into the Timmer chicane on the final lap.
Mir lost time in the last few laps and also fell behind the LCR Honda rider Cal Crutchlow, settle for the eighth.
Pramac Ducatis Jack Miller finished ninth while Andrea Iannone got his first top 10 result on an Aprilia.
Pol Espargaro was the best KTM in 11th place Johann Zarco, who was 10th early on, retired in the pits.
Valentino Rossi had a quick crash with Takaaki Nakagami At Turn 8, the Japanese driver was visibly injured after the incident and was taken to the medical center for a check-up Charles Abraham also fell in turn 3.